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The Facilities for Illness Management and Prevention (CDC) warns of the potential for “COVID-19 rebound” after sufferers take the oral antiviral drug known as Paxlovid. The therapy is allowed underneath emergency use by the Meals and Drug Administration for grownup and pediatric sufferers with mild-to-moderate COVID-19 who’re in danger for extreme illness.
“If you take Paxlovid, you might get symptoms again,” CDC director Dr. Rochelle Walensky stated. “We haven’t yet seen anybody who has returned with symptoms needing to go to the hospital. So, generally, a milder course.”
COVID-19 rebound is a return of COVID-19 signs or a brand new constructive viral check (after testing damaging) between two and eight days after getting higher.
However the company famous some individuals might expertise the temporary rebound of signs as a part of the pure course of the illness and “independent of treatment with Paxlovid and regardless of vaccination status,” in line with a current CDC Well being Alert Community Well being Advisory.
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The company continues to advocate the antiviral therapy as Paxlovid helps stop hospitalization and demise attributable to COVID-19. It must be taken inside 5 days of symptom onset.
“Both the recurrence of illness and positive test results improved or resolved (median of 3 days) without additional anti-COVID-19 treatment. Based on information from the case reports, COVID-19 rebound did not represent reinfection with SARS-CoV-2 or the development of resistance to Paxlovid; also, no other respiratory pathogens were identified among known cases,” the CDC stated.
It’s attainable to transmit the an infection whereas experiencing COVID-19 rebound, however it’s unknown at this level how the probability of transmission throughout rebound compares to the probability of transmission throughout the preliminary an infection.
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The company added there isn’t a proof Paxlovid must be prolonged or every other antiviral therapies are wanted for COVID-19 rebound, however the threat of transmission throughout this era will be managed by following CDC’s guidance on isolation.
For individuals who expertise COVID-19 rebound, Walensky suggested: “They should test. They should put their mask back on. And if their test is positive, restart the isolation protocol.”